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Estrace (estradiol vaginal cream) costs $29–$55 per tube in Canada. The cheapest option is Costco at $28.49 per tube. Last updated: 2026-02-26.

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Compare Estrace

Pharmacy Price Comparison

PharmacyDrugFeeTotalNote
Costco$24.00 per tube$4.49$28.49 per tubeCheapestNo membership needed
Walmart$34.00 per tube$9.97$43.97 per tube
Rexall$38.00 per tube$12.99$50.99 per tube
Shoppers Drug Mart$42.00 per tube$12.99$54.99 per tube

Provincial Coverage

Ontario Drug Benefit (ODB)

General Benefit

How to Save

Cheapest Pharmacy

Costco

$28.49 per tube

Save $26.50 per tube vs. Shoppers Drug Mart

Medical expense tax credit: eligible prescription costs may count toward the federal medical expense tax credit; CRA applies the lesser of 3% of net income or the annual threshold.

Drug Information

Brand Name
Estrace
Generic Name
estradiol vaginal cream
Category
Menopause
Route
Vaginal cream
Price Range
$29–$55 per tube

Similar Medications

Other menopause medications available in Canada with pharmacy pricing:

Frequently Asked Questions

How much does Estrace cost in Canada?
Estrace costs $29–$55 per tube in Canada. Costco offers the lowest price at $28.49 per tube.

Sources

Pharmacy prices were obtained through direct pharmacy inquiries for the listed package/unit, or for a standard 30-day supply when no package-specific unit is shown. Canadian pharmacies do not publish prescription drug prices online. Price ranges are rounded listed-basis estimates. Displayed pharmacy totals include dispensing fees; separate drug columns show the medication/package amount before the fee. Prices may vary by location, dosage, quantity, and supply. Provincial coverage data is sourced from each province's public formulary database. Coverage criteria and terminology differ between provinces.

  1. Costco PricingCostco Pharmacy Canada — price verified via pharmacy inquiryAccessed 2026-02-01
  2. Walmart PricingWalmart Pharmacy — price verified via pharmacy inquiryAccessed 2026-02-01
  3. Rexall PricingRexall Pharmacy — price verified via pharmacy inquiryAccessed 2026-02-01
  4. Shoppers PricingShoppers Drug Mart — price verified via pharmacy inquiryAccessed 2026-02-01
  5. ODB Formulary StatusOntario Drug Benefit Formulary — estradiol vaginal creamAccessed 2026-01-15
  6. Drug Product InformationHealth Canada Drug Product Database — EstraceAccessed 2026-02-26

Last updated: 2026-02-26

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