Menopause Comparison
Estrace vs Vagifem
Price comparison in Canada
Estrace starts at $29.00 per month, while Vagifem starts at $45.00 per month in Canada. Estrace contains estradiol vaginal cream, while Vagifem contains estradiol vaginal tablet. Last updated: 2026-02-26.
Head-to-Head Comparison
| Estrace | Vagifem | |
|---|---|---|
| Price Range | $29–$55 per month | $45–$81 per month |
| Cheapest Pharmacy | Costco ($28.49 per month) | Costco ($44.49 per month) |
| Generic Name | estradiol vaginal cream | estradiol vaginal tablet |
| Route | Vaginal cream | Vaginal tablet |
| Category | Menopause | Menopause |
| ODB Coverage | General Benefit | General Benefit |
Pharmacy Total Breakdown
| Pharmacy | Estrace | Vagifem |
|---|---|---|
| Costco | $28.49 per month | $44.49 per month |
| Walmart | $43.97 per month | $64.97 per month |
| Rexall | $50.99 per month | $74.99 per month |
| Shoppers Drug Mart | $54.99 per month | $80.99 per month |
Full Drug Pages
Frequently Asked Questions
- Which is cheaper, Estrace or Vagifem?
- Estrace is generally cheaper, starting at $29.00 per month compared to $45.00 per month for Vagifem. The lowest price is at Costco ($28.49 per month).
- What is the difference between Estrace and Vagifem?
- Estrace (estradiol vaginal cream) and Vagifem (estradiol vaginal tablet) are different medications in the menopause category. Estrace is a vaginal cream, while Vagifem is a vaginal tablet.
- Is Estrace or Vagifem covered by provincial drug plans?
- Estrace: General Benefit on the Ontario Drug Benefit formulary. Vagifem: General Benefit on the Ontario Drug Benefit formulary.
Last updated: 2026-02-26