Menopause Comparison
Estrace vs Vagifem
Price comparison in Canada
Estrace is listed at $29.00 per tube, while Vagifem is listed at $45.00 per pack in Canada. These listed prices use different bases, so compare final cost using the prescribed dose and fill quantity. Estrace contains estradiol vaginal cream, while Vagifem contains estradiol vaginal tablet. Last updated: 2026-02-26.
Head-to-Head Comparison
| Estrace | Vagifem | |
|---|---|---|
| Listed Price Basis | per tube | per pack |
| Price Range | $29–$55 per tube | $45–$81 per pack |
| Cheapest Pharmacy | Costco ($28.49 per tube) | Costco ($44.49 per pack) |
| Generic Name | estradiol vaginal cream | estradiol vaginal tablet |
| Route | Vaginal cream | Vaginal tablet |
| Category | Menopause | Menopause |
| ODB Coverage | General Benefit | General Benefit |
Pharmacy Total Breakdown
| Pharmacy | Estrace | Vagifem |
|---|---|---|
| Costco | $28.49 per tube | $44.49 per pack |
| Walmart | $43.97 per tube | $64.97 per pack |
| Rexall | $50.99 per tube | $74.99 per pack |
| Shoppers Drug Mart | $54.99 per tube | $80.99 per pack |
Full Drug Pages
Frequently Asked Questions
- Which is cheaper, Estrace or Vagifem?
- Estrace and Vagifem are listed on different price bases, so the listed prices are not directly comparable. Estrace ranges $29–$55 per tube; Vagifem ranges $45–$81 per pack. Compare final cost using the prescribed dose and fill quantity.
- What is the difference between Estrace and Vagifem?
- Estrace (estradiol vaginal cream) and Vagifem (estradiol vaginal tablet) are different medications in the menopause category. Estrace is a vaginal cream, while Vagifem is a vaginal tablet.
- Is Estrace or Vagifem covered by provincial drug plans?
- Estrace: General Benefit on the Ontario Drug Benefit formulary. Vagifem: General Benefit on the Ontario Drug Benefit formulary.
Last updated: 2026-02-26