Which is cheaper, Zoryve or Enstilar?

Zoryve and Enstilar are listed on different price bases, so the listed prices are not directly comparable. Zoryve ranges $345–$533 per tube; Enstilar ranges $110–$178 per can. Compare final cost using the prescribed dose and fill quantity.

What is the difference between Zoryve and Enstilar?

Zoryve (roflumilast topical) and Enstilar (calcipotriol/betamethasone) are different medications in the dermatology category. Zoryve is a topical cream, while Enstilar is a topical foam.

Zoryve vs Enstilar: Price Comparison in Canada (2026)

Name: Zoryve vs Enstilar: Price Comparison in Canada (2026)
Creator: TeleTest
Published: 2026-02-26

Zoryve is listed at $345.00 per tube, while Enstilar is listed at $110.00 per can in Canada. These listed prices use different bases, so compare final cost using the prescribed dose and fill quantity. Zoryve contains roflumilast topical, while Enstilar contains calcipotriol/betamethasone. Last updated: 2026-02-26.

Head-to-Head Comparison

	Zoryve	Enstilar
Listed Price Basis	per tube	per can
Price Range	$345–$533 per tube	$110–$178 per can
Cheapest Pharmacy	Costco ($344.49 per tube)	Costco ($109.49 per can)
Generic Name	roflumilast topical	calcipotriol/betamethasone
Route	Topical cream	Topical foam
Category	Dermatology	Dermatology

Pharmacy Total Breakdown

Pharmacy	Zoryve	Enstilar
Costco	$344.49 per tube	$109.49 per can
Walmart	$429.97 per tube	$139.97 per can
Rexall	$482.99 per tube	$162.99 per can
Shoppers Drug Mart	$532.99 per tube	$177.99 per can

Full Drug Pages

Zoryve roflumilast topical $345–$533 per tube Enstilar calcipotriol/betamethasone $110–$178 per can

Frequently Asked Questions

Which is cheaper, Zoryve or Enstilar?: Zoryve and Enstilar are listed on different price bases, so the listed prices are not directly comparable. Zoryve ranges $345–$533 per tube; Enstilar ranges $110–$178 per can. Compare final cost using the prescribed dose and fill quantity.
What is the difference between Zoryve and Enstilar?: Zoryve (roflumilast topical) and Enstilar (calcipotriol/betamethasone) are different medications in the dermatology category. Zoryve is a topical cream, while Enstilar is a topical foam.

Last updated: 2026-02-26