Which is cheaper, Zoryve or Enstilar?

Enstilar is generally cheaper, starting at $110.00/mo compared to $350.00/mo for Zoryve. The lowest price is at Costco ($105.00/mo).

What is the difference between Zoryve and Enstilar?

Zoryve (roflumilast topical) and Enstilar (calcipotriol/betamethasone) are different medications in the dermatology category. Zoryve is a topical cream, while Enstilar is a topical foam.

Zoryve vs Enstilar: Price Comparison in Canada (2026)

Name: Zoryve vs Enstilar: Price Comparison in Canada (2026)
Creator: TeleTest
Published: 2026-02-26

Enstilar starts at $110/mo, while Zoryve starts at $350/mo in Canada. Zoryve contains roflumilast topical, while Enstilar contains calcipotriol/betamethasone. Last updated: 2026-02-26.

Head-to-Head Comparison

	Zoryve	Enstilar
Price Range	$350–$550/mo	$110–$180/mo
Cheapest Pharmacy	Costco ($340.00/mo)	Costco ($105.00/mo)
Generic Name	roflumilast topical	calcipotriol/betamethasone
Route	Topical cream	Topical foam
Category	Dermatology	Dermatology

Pharmacy Price Breakdown

Pharmacy	Zoryve	Enstilar
Costco	$340.00/mo	$105.00/mo
Walmart	$420.00/mo	$130.00/mo
Rexall	$470.00/mo	$150.00/mo
Shoppers Drug Mart	$520.00/mo	$165.00/mo

Full Drug Pages

Zoryve roflumilast topical $350–$550/mo Enstilar calcipotriol/betamethasone $110–$180/mo

Frequently Asked Questions

Which is cheaper, Zoryve or Enstilar?: Enstilar is generally cheaper, starting at $110.00/mo compared to $350.00/mo for Zoryve. The lowest price is at Costco ($105.00/mo).
What is the difference between Zoryve and Enstilar?: Zoryve (roflumilast topical) and Enstilar (calcipotriol/betamethasone) are different medications in the dermatology category. Zoryve is a topical cream, while Enstilar is a topical foam.

Last updated: 2026-02-26