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Protopic starts at $65/mo, while Eucrisa starts at $250/mo in Canada. Eucrisa contains crisaborole, while Protopic contains tacrolimus 0.1%. Last updated: 2026-02-26.

Head-to-Head Comparison

Eucrisa Protopic
Price Range $250–$380/mo $65–$100/mo
Cheapest Pharmacy Costco ($240.00/mo) Costco ($60.00/mo)
Generic Name crisaborole tacrolimus 0.1%
Route Topical ointment Topical ointment
Category Dermatology Dermatology

Pharmacy Price Breakdown

Pharmacy Eucrisa Protopic
Costco $240.00/mo $60.00/mo
Walmart $300.00/mo $75.00/mo
Rexall $330.00/mo $82.00/mo
Shoppers Drug Mart $360.00/mo $90.00/mo

Frequently Asked Questions

Which is cheaper, Eucrisa or Protopic?
Protopic is generally cheaper, starting at $65.00/mo compared to $250.00/mo for Eucrisa. The lowest price is at Costco ($60.00/mo).
What is the difference between Eucrisa and Protopic?
Eucrisa (crisaborole) and Protopic (tacrolimus 0.1%) are different medications in the dermatology category.

Last updated: 2026-02-26

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