Which is cheaper, Estrace or Vagifem?

Estrace is generally cheaper, starting at $28.00/mo compared to $45.00/mo for Vagifem. The lowest price is at Costco ($24.00/mo).

What is the difference between Estrace and Vagifem?

Estrace (estradiol vaginal cream) and Vagifem (estradiol vaginal tablet) are different medications in the menopause category. Estrace is a vaginal cream, while Vagifem is a vaginal tablet.

Is Estrace or Vagifem covered by provincial drug plans?

Estrace: General Benefit on the Ontario Drug Benefit formulary. Vagifem: General Benefit on the Ontario Drug Benefit formulary.

Estrace vs Vagifem: Price Comparison in Canada (2026)

Name: Estrace vs Vagifem: Price Comparison in Canada (2026)
Creator: TeleTest
Published: 2026-02-26

Estrace starts at $28/mo, while Vagifem starts at $45/mo in Canada. Estrace contains estradiol vaginal cream, while Vagifem contains estradiol vaginal tablet. Last updated: 2026-02-26.

Head-to-Head Comparison

	Estrace	Vagifem
Price Range	$28–$48/mo	$45–$72/mo
Cheapest Pharmacy	Costco ($24.00/mo)	Costco ($40.00/mo)
Generic Name	estradiol vaginal cream	estradiol vaginal tablet
Route	Vaginal cream	Vaginal tablet
Category	Menopause	Menopause
ODB Coverage	General Benefit	General Benefit

Pharmacy Price Breakdown

Pharmacy	Estrace	Vagifem
Costco	$24.00/mo	$40.00/mo
Walmart	$34.00/mo	$55.00/mo
Rexall	$38.00/mo	$62.00/mo
Shoppers Drug Mart	$42.00/mo	$68.00/mo

Full Drug Pages

Estrace estradiol vaginal cream $28–$48/mo Vagifem estradiol vaginal tablet $45–$72/mo

Frequently Asked Questions

Which is cheaper, Estrace or Vagifem?: Estrace is generally cheaper, starting at $28.00/mo compared to $45.00/mo for Vagifem. The lowest price is at Costco ($24.00/mo).
What is the difference between Estrace and Vagifem?: Estrace (estradiol vaginal cream) and Vagifem (estradiol vaginal tablet) are different medications in the menopause category. Estrace is a vaginal cream, while Vagifem is a vaginal tablet.
Is Estrace or Vagifem covered by provincial drug plans?: Estrace: General Benefit on the Ontario Drug Benefit formulary. Vagifem: General Benefit on the Ontario Drug Benefit formulary.

Last updated: 2026-02-26