Dermatology Comparison
Adapalene vs Trifarotene
Price comparison in Canada
Adapalene starts at $17.00 per tube, while Trifarotene starts at $70.00 per tube in Canada. Adapalene contains adapalene (Differin), while Trifarotene contains trifarotene (Aklief). Last updated: 2026-02-26.
Head-to-Head Comparison
| Adapalene | Trifarotene | |
|---|---|---|
| Price Range | $17–$38 per tube | $70–$115 per tube |
| Cheapest Pharmacy | Costco ($16.49 per tube) | Costco ($69.49 per tube) |
| Generic Name | adapalene (Differin) | trifarotene (Aklief) |
| Route | Topical gel | Topical cream |
| Category | Dermatology | Dermatology |
| ODB Coverage | General Benefit | Not listed |
Pharmacy Total Breakdown
| Pharmacy | Adapalene | Trifarotene |
|---|---|---|
| Costco | $16.49 per tube | $69.49 per tube |
| Walmart | $27.97 per tube | $91.97 per tube |
| Rexall | $34.99 per tube | $104.99 per tube |
| Shoppers Drug Mart | $37.99 per tube | $114.99 per tube |
Full Drug Pages
Frequently Asked Questions
- Which is cheaper, Adapalene or Trifarotene?
- Adapalene is generally cheaper, starting at $17.00 per tube compared to $70.00 per tube for Trifarotene. The lowest price is at Costco ($16.49 per tube).
- What is the difference between Adapalene and Trifarotene?
- Adapalene (adapalene (Differin)) and Trifarotene (trifarotene (Aklief)) are different medications in the dermatology category. Adapalene is a topical gel, while Trifarotene is a topical cream.
- Is Adapalene or Trifarotene covered by provincial drug plans?
- Adapalene: General Benefit on the Ontario Drug Benefit formulary.
Last updated: 2026-02-26