Dermatology Comparison
Adapalene vs Trifarotene
Price comparison in Canada
Adapalene starts at $15/mo, while Trifarotene starts at $70/mo in Canada. Adapalene contains adapalene (Differin), while Trifarotene contains trifarotene (Aklief). Last updated: 2026-02-26.
Head-to-Head Comparison
| Adapalene | Trifarotene | |
|---|---|---|
| Price Range | $15–$28/mo | $70–$110/mo |
| Cheapest Pharmacy | Costco ($12.00/mo) | Costco ($65.00/mo) |
| Generic Name | adapalene (Differin) | trifarotene (Aklief) |
| Route | Topical gel | Topical cream |
| Category | Dermatology | Dermatology |
| ODB Coverage | General Benefit | Not listed |
Pharmacy Price Breakdown
| Pharmacy | Adapalene | Trifarotene |
|---|---|---|
| Costco | $12.00/mo | $65.00/mo |
| Walmart | $18.00/mo | $82.00/mo |
| Rexall | $22.00/mo | $92.00/mo |
| Shoppers Drug Mart | $25.00/mo | $102.00/mo |
Full Drug Pages
Frequently Asked Questions
- Which is cheaper, Adapalene or Trifarotene?
- Adapalene is generally cheaper, starting at $15.00/mo compared to $70.00/mo for Trifarotene. The lowest price is at Costco ($12.00/mo).
- What is the difference between Adapalene and Trifarotene?
- Adapalene (adapalene (Differin)) and Trifarotene (trifarotene (Aklief)) are different medications in the dermatology category. Adapalene is a topical gel, while Trifarotene is a topical cream.
- Is Adapalene or Trifarotene covered by provincial drug plans?
- Adapalene: General Benefit on the Ontario Drug Benefit formulary.
Last updated: 2026-02-26