Smoking Cessation Comparison
Varenicline vs Zyban
Price comparison in Canada
Zyban starts at $22/mo, while Varenicline starts at $42/mo in Canada. Varenicline contains varenicline (Champix), while Zyban contains bupropion 150mg. Last updated: 2026-02-26.
Head-to-Head Comparison
| Varenicline | Zyban | |
|---|---|---|
| Price Range | $42–$75/mo | $22–$38/mo |
| Cheapest Pharmacy | Costco ($38.00/mo) | Costco ($18.00/mo) |
| Generic Name | varenicline (Champix) | bupropion 150mg |
| Route | Oral tablet | Oral tablet |
| Category | Smoking Cessation | Smoking Cessation |
| ODB Coverage | General Benefit | General Benefit |
Pharmacy Price Breakdown
| Pharmacy | Varenicline | Zyban |
|---|---|---|
| Costco | $38.00/mo | $18.00/mo |
| Walmart | $52.00/mo | $26.00/mo |
| Rexall | $58.00/mo | $30.00/mo |
| Shoppers Drug Mart | $65.00/mo | $34.00/mo |
Full Drug Pages
Frequently Asked Questions
- Which is cheaper, Varenicline or Zyban?
- Zyban is generally cheaper, starting at $22.00/mo compared to $42.00/mo for Varenicline. The lowest price is at Costco ($18.00/mo).
- What is the difference between Varenicline and Zyban?
- Varenicline (varenicline (Champix)) and Zyban (bupropion 150mg) are different medications in the smoking cessation category.
- Is Varenicline or Zyban covered by provincial drug plans?
- Varenicline: General Benefit on the Ontario Drug Benefit formulary. Zyban: General Benefit on the Ontario Drug Benefit formulary.
Last updated: 2026-02-26