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Acyclovir starts at $10/mo, while Valacyclovir starts at $18/mo in Canada. Valacyclovir contains valacyclovir 500–1000mg, while Acyclovir contains acyclovir. Last updated: 2026-02-26.

Head-to-Head Comparison

Valacyclovir Acyclovir
Price Range $18–$38/mo $10–$22/mo
Cheapest Pharmacy Costco ($14.80/mo) Costco ($7.50/mo)
Generic Name valacyclovir 500–1000mg acyclovir
Route Oral tablet Oral/topical
Category Antiviral Antiviral
ODB Coverage General Benefit General Benefit

Pharmacy Price Breakdown

Pharmacy Valacyclovir Acyclovir
Costco $14.80/mo $7.50/mo
Walmart $20.40/mo $12.50/mo
Rexall $23.60/mo $15.00/mo
Shoppers Drug Mart $26.20/mo $17.00/mo

Frequently Asked Questions

Which is cheaper, Valacyclovir or Acyclovir?
Acyclovir is generally cheaper, starting at $10.00/mo compared to $18.00/mo for Valacyclovir. The lowest price is at Costco ($7.50/mo).
What is the difference between Valacyclovir and Acyclovir?
Valacyclovir (valacyclovir 500–1000mg) and Acyclovir (acyclovir) are different medications in the antiviral category. Valacyclovir is a oral tablet, while Acyclovir is a oral/topical.
Is Valacyclovir or Acyclovir covered by provincial drug plans?
Valacyclovir: General Benefit on the Ontario Drug Benefit formulary. Acyclovir: General Benefit on the Ontario Drug Benefit formulary.

Last updated: 2026-02-26

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