Dermatology Comparison
Tretinoin vs Trifarotene
Price comparison in Canada
Tretinoin starts at $20.00 per tube, while Trifarotene starts at $70.00 per tube in Canada. Tretinoin contains tretinoin 0.025–0.1%, while Trifarotene contains trifarotene (Aklief). Last updated: 2026-02-26.
Head-to-Head Comparison
| Tretinoin | Trifarotene | |
|---|---|---|
| Price Range | $20–$43 per tube | $70–$115 per tube |
| Cheapest Pharmacy | Costco ($19.49 per tube) | Costco ($69.49 per tube) |
| Generic Name | tretinoin 0.025–0.1% | trifarotene (Aklief) |
| Route | Topical cream/gel | Topical cream |
| Category | Dermatology | Dermatology |
| ODB Coverage | General Benefit | Not listed |
Pharmacy Total Breakdown
| Pharmacy | Tretinoin | Trifarotene |
|---|---|---|
| Costco | $19.49 per tube | $69.49 per tube |
| Walmart | $31.97 per tube | $91.97 per tube |
| Rexall | $38.99 per tube | $104.99 per tube |
| Shoppers Drug Mart | $42.99 per tube | $114.99 per tube |
Full Drug Pages
Frequently Asked Questions
- Which is cheaper, Tretinoin or Trifarotene?
- Tretinoin is generally cheaper, starting at $20.00 per tube compared to $70.00 per tube for Trifarotene. The lowest price is at Costco ($19.49 per tube).
- What is the difference between Tretinoin and Trifarotene?
- Tretinoin (tretinoin 0.025–0.1%) and Trifarotene (trifarotene (Aklief)) are different medications in the dermatology category. Tretinoin is a topical cream/gel, while Trifarotene is a topical cream.
- Is Tretinoin or Trifarotene covered by provincial drug plans?
- Tretinoin: General Benefit on the Ontario Drug Benefit formulary.
Last updated: 2026-02-26