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Sertraline starts at $10.00 per month, while Paroxetine starts at $11.00 per month in Canada. Sertraline contains sertraline (Zoloft), while Paroxetine contains paroxetine (Paxil). Last updated: 2026-02-26.

Head-to-Head Comparison

Sertraline Paroxetine
Price Range $10–$28 per month $11–$29 per month
Cheapest Pharmacy Costco ($9.49 per month) Costco ($10.99 per month)
Generic Name sertraline (Zoloft) paroxetine (Paxil)
Route Oral tablet Oral tablet
Category Mental Health Mental Health
ODB Coverage General Benefit General Benefit

Pharmacy Total Breakdown

Pharmacy Sertraline Paroxetine
Costco $9.49 per month $10.99 per month
Walmart $19.97 per month $21.47 per month
Rexall $25.49 per month $26.99 per month
Shoppers Drug Mart $27.49 per month $28.99 per month

Frequently Asked Questions

Which is cheaper, Sertraline or Paroxetine?
Sertraline is generally cheaper, starting at $10.00 per month compared to $11.00 per month for Paroxetine. The lowest price is at Costco ($9.49 per month).
What is the difference between Sertraline and Paroxetine?
Sertraline (sertraline (Zoloft)) and Paroxetine (paroxetine (Paxil)) are different medications in the mental health category.
Is Sertraline or Paroxetine covered by provincial drug plans?
Sertraline: General Benefit on the Ontario Drug Benefit formulary. Paroxetine: General Benefit on the Ontario Drug Benefit formulary.

Last updated: 2026-02-26