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Sertraline starts at $8/mo, while Paroxetine starts at $10/mo in Canada. Sertraline contains sertraline (Zoloft), while Paroxetine contains paroxetine (Paxil). Last updated: 2026-02-26.

Head-to-Head Comparison

Sertraline Paroxetine
Price Range $8–$20/mo $10–$22/mo
Cheapest Pharmacy Costco ($5.00/mo) Costco ($6.50/mo)
Generic Name sertraline (Zoloft) paroxetine (Paxil)
Route Oral tablet Oral tablet
Category Mental Health Mental Health
ODB Coverage General Benefit General Benefit

Pharmacy Price Breakdown

Pharmacy Sertraline Paroxetine
Costco $5.00/mo $6.50/mo
Walmart $10.00/mo $11.50/mo
Rexall $12.50/mo $14.00/mo
Shoppers Drug Mart $14.50/mo $16.00/mo

Frequently Asked Questions

Which is cheaper, Sertraline or Paroxetine?
Sertraline is generally cheaper, starting at $8.00/mo compared to $10.00/mo for Paroxetine. The lowest price is at Costco ($5.00/mo).
What is the difference between Sertraline and Paroxetine?
Sertraline (sertraline (Zoloft)) and Paroxetine (paroxetine (Paxil)) are different medications in the mental health category.
Is Sertraline or Paroxetine covered by provincial drug plans?
Sertraline: General Benefit on the Ontario Drug Benefit formulary. Paroxetine: General Benefit on the Ontario Drug Benefit formulary.

Last updated: 2026-02-26

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