Mental Health Comparison
Sertraline vs Duloxetine
Price comparison in Canada
Sertraline starts at $8/mo, while Duloxetine starts at $12/mo in Canada. Sertraline contains sertraline (Zoloft), while Duloxetine contains duloxetine (Cymbalta). Last updated: 2026-02-26.
Head-to-Head Comparison
| Sertraline | Duloxetine | |
|---|---|---|
| Price Range | $8–$20/mo | $12–$25/mo |
| Cheapest Pharmacy | Costco ($5.00/mo) | Costco ($8.00/mo) |
| Generic Name | sertraline (Zoloft) | duloxetine (Cymbalta) |
| Route | Oral tablet | Oral tablet |
| Category | Mental Health | Mental Health |
| ODB Coverage | General Benefit | General Benefit |
Pharmacy Price Breakdown
| Pharmacy | Sertraline | Duloxetine |
|---|---|---|
| Costco | $5.00/mo | $8.00/mo |
| Walmart | $10.00/mo | $14.00/mo |
| Rexall | $12.50/mo | $17.00/mo |
| Shoppers Drug Mart | $14.50/mo | $19.50/mo |
Full Drug Pages
Frequently Asked Questions
- Which is cheaper, Sertraline or Duloxetine?
- Sertraline is generally cheaper, starting at $8.00/mo compared to $12.00/mo for Duloxetine. The lowest price is at Costco ($5.00/mo).
- What is the difference between Sertraline and Duloxetine?
- Sertraline (sertraline (Zoloft)) and Duloxetine (duloxetine (Cymbalta)) are different medications in the mental health category.
- Is Sertraline or Duloxetine covered by provincial drug plans?
- Sertraline: General Benefit on the Ontario Drug Benefit formulary. Duloxetine: General Benefit on the Ontario Drug Benefit formulary.
Last updated: 2026-02-26