Weight Loss Comparison
Rybelsus vs Contrave
Price comparison in Canada
Contrave starts at $280.00 per month, while Rybelsus starts at $354.00 per month in Canada. Rybelsus contains semaglutide (oral), while Contrave contains naltrexone/bupropion. Last updated: 2026-02-26.
Head-to-Head Comparison
| Rybelsus | Contrave | |
|---|---|---|
| Price Range | $354–$365 per month | $280–$450 per month |
| Cheapest Pharmacy | N/A | N/A |
| Generic Name | semaglutide (oral) | naltrexone/bupropion |
| Route | Daily oral tablet | Oral (twice daily) |
| Category | Weight Loss | Weight Loss |
| ODB Coverage | Limited Use | Not Covered |
| Coverage Notes | Limited Use (Type 2 Diabetes only in ON) | Not covered |
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Frequently Asked Questions
- Which is cheaper, Rybelsus or Contrave?
- Contrave is generally cheaper, starting at $280.00 per month compared to $354.00 per month for Rybelsus.
- What is the difference between Rybelsus and Contrave?
- Rybelsus (semaglutide (oral)) and Contrave (naltrexone/bupropion) are different medications in the weight loss category. Rybelsus is a daily oral tablet, while Contrave is an oral (twice daily).
- Is Rybelsus or Contrave covered by provincial drug plans?
- Rybelsus: Limited Use on the Ontario Drug Benefit formulary. Contrave: Not Covered on the Ontario Drug Benefit formulary.
Last updated: 2026-02-26