Weight Loss Comparison
Ozempic vs Rybelsus
Price comparison in Canada
Ozempic starts at $258.00 per month, while Rybelsus starts at $354.00 per month in Canada. Ozempic contains semaglutide, while Rybelsus contains semaglutide (oral). Last updated: 2026-02-26.
Head-to-Head Comparison
| Ozempic | Rybelsus | |
|---|---|---|
| Price Range | $258–$291 per month | $354–$365 per month |
| Cheapest Pharmacy | Costco ($257.47 per month) | N/A |
| Generic Name | semaglutide | semaglutide (oral) |
| Route | Weekly injection | Daily oral tablet |
| Category | Weight Loss | Weight Loss |
| ODB Coverage | Limited Use | Limited Use |
| Coverage Notes | Limited Use (Type 2 Diabetes only in ON) | Limited Use (Type 2 Diabetes only in ON) |
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Frequently Asked Questions
- Which is cheaper, Ozempic or Rybelsus?
- Ozempic is generally cheaper, starting at $258.00 per month compared to $354.00 per month for Rybelsus. The lowest price is at Costco ($257.47 per month).
- What is the difference between Ozempic and Rybelsus?
- Ozempic (semaglutide) and Rybelsus (semaglutide (oral)) are different medications in the weight loss category. Ozempic is a weekly injection, while Rybelsus is a daily oral tablet.
- Is Ozempic or Rybelsus covered by provincial drug plans?
- Ozempic: Limited Use on the Ontario Drug Benefit formulary. Rybelsus: Limited Use on the Ontario Drug Benefit formulary.
Last updated: 2026-02-26