Which is cheaper, Ozempic or Rybelsus?

Ozempic is generally cheaper, starting at $253.00/mo compared to $354.00/mo for Rybelsus. The lowest price is at Costco ($252.98/mo).

What is the difference between Ozempic and Rybelsus?

Ozempic (semaglutide) and Rybelsus (semaglutide (oral)) are different medications in the weight loss category. Ozempic is a weekly injection, while Rybelsus is a daily oral tablet.

Is Ozempic or Rybelsus covered by provincial drug plans?

Ozempic: Limited Use on the Ontario Drug Benefit formulary. Rybelsus: Limited Use on the Ontario Drug Benefit formulary.

Ozempic vs Rybelsus: Price Comparison in Canada (2026)

Name: Ozempic vs Rybelsus: Price Comparison in Canada (2026)
Creator: TeleTest
Published: 2026-02-26

Ozempic starts at $253/mo, while Rybelsus starts at $354/mo in Canada. Ozempic contains semaglutide, while Rybelsus contains semaglutide (oral). Last updated: 2026-02-26.

Head-to-Head Comparison

	Ozempic	Rybelsus
Price Range	$253–$308/mo	$354–$365/mo
Cheapest Pharmacy	Costco ($252.98/mo)	N/A
Generic Name	semaglutide	semaglutide (oral)
Route	Weekly injection	Daily oral tablet
Category	Weight Loss	Weight Loss
ODB Coverage	Limited Use	Limited Use
Coverage Notes	Limited Use (Type 2 Diabetes only in ON)	Limited Use (Type 2 Diabetes only in ON)

Full Drug Pages

Ozempic semaglutide $253–$308/mo Rybelsus semaglutide (oral) $354–$365/mo

Frequently Asked Questions

Which is cheaper, Ozempic or Rybelsus?: Ozempic is generally cheaper, starting at $253.00/mo compared to $354.00/mo for Rybelsus. The lowest price is at Costco ($252.98/mo).
What is the difference between Ozempic and Rybelsus?: Ozempic (semaglutide) and Rybelsus (semaglutide (oral)) are different medications in the weight loss category. Ozempic is a weekly injection, while Rybelsus is a daily oral tablet.
Is Ozempic or Rybelsus covered by provincial drug plans?: Ozempic: Limited Use on the Ontario Drug Benefit formulary. Rybelsus: Limited Use on the Ontario Drug Benefit formulary.

Last updated: 2026-02-26