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Omeprazole starts at $10.00 per month, while Esomeprazole starts at $13.00 per month in Canada. Omeprazole contains omeprazole (Losec), while Esomeprazole contains esomeprazole (Nexium). Last updated: 2026-02-26.

Head-to-Head Comparison

Omeprazole Esomeprazole
Price Range $10–$28 per month $13–$33 per month
Cheapest Pharmacy Costco ($9.49 per month) Costco ($12.49 per month)
Generic Name omeprazole (Losec) esomeprazole (Nexium)
Route Oral capsule Oral capsule
Category GI GI
ODB Coverage General Benefit General Benefit

Pharmacy Total Breakdown

Pharmacy Omeprazole Esomeprazole
Costco $9.49 per month $12.49 per month
Walmart $19.97 per month $23.97 per month
Rexall $25.49 per month $29.99 per month
Shoppers Drug Mart $27.49 per month $32.49 per month

Frequently Asked Questions

Which is cheaper, Omeprazole or Esomeprazole?
Omeprazole is generally cheaper, starting at $10.00 per month compared to $13.00 per month for Esomeprazole. The lowest price is at Costco ($9.49 per month).
What is the difference between Omeprazole and Esomeprazole?
Omeprazole (omeprazole (Losec)) and Esomeprazole (esomeprazole (Nexium)) are different medications in the gi category.
Is Omeprazole or Esomeprazole covered by provincial drug plans?
Omeprazole: General Benefit on the Ontario Drug Benefit formulary. Esomeprazole: General Benefit on the Ontario Drug Benefit formulary.

Last updated: 2026-02-26

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