GI Comparison
Omeprazole vs Esomeprazole
Price comparison in Canada
Omeprazole starts at $8/mo, while Esomeprazole starts at $12/mo in Canada. Omeprazole contains omeprazole (Losec), while Esomeprazole contains esomeprazole (Nexium). Last updated: 2026-02-26.
Head-to-Head Comparison
| Omeprazole | Esomeprazole | |
|---|---|---|
| Price Range | $8–$20/mo | $12–$25/mo |
| Cheapest Pharmacy | Costco ($5.00/mo) | Costco ($8.00/mo) |
| Generic Name | omeprazole (Losec) | esomeprazole (Nexium) |
| Route | Oral capsule | Oral capsule |
| Category | GI | GI |
| ODB Coverage | General Benefit | General Benefit |
Pharmacy Price Breakdown
| Pharmacy | Omeprazole | Esomeprazole |
|---|---|---|
| Costco | $5.00/mo | $8.00/mo |
| Walmart | $10.00/mo | $14.00/mo |
| Rexall | $12.50/mo | $17.00/mo |
| Shoppers Drug Mart | $14.50/mo | $19.50/mo |
Full Drug Pages
Frequently Asked Questions
- Which is cheaper, Omeprazole or Esomeprazole?
- Omeprazole is generally cheaper, starting at $8.00/mo compared to $12.00/mo for Esomeprazole. The lowest price is at Costco ($5.00/mo).
- What is the difference between Omeprazole and Esomeprazole?
- Omeprazole (omeprazole (Losec)) and Esomeprazole (esomeprazole (Nexium)) are different medications in the gi category.
- Is Omeprazole or Esomeprazole covered by provincial drug plans?
- Omeprazole: General Benefit on the Ontario Drug Benefit formulary. Esomeprazole: General Benefit on the Ontario Drug Benefit formulary.
Last updated: 2026-02-26