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Lantus starts at $55.00 per box of 5 pens, while Tresiba starts at $85.00 per box of 5 pens in Canada. Lantus contains insulin glargine, while Tresiba contains insulin degludec. Last updated: 2026-02-26.

Head-to-Head Comparison

Lantus Tresiba
Price Range $55–$93 per box of 5 pens $85–$133 per box of 5 pens
Cheapest Pharmacy Costco ($54.49 per box of 5 pens) Costco ($84.49 per box of 5 pens)
Generic Name insulin glargine insulin degludec
Route Injection Injection
Category Diabetes Diabetes
ODB Coverage General Benefit General Benefit

Pharmacy Total Breakdown

Pharmacy Lantus Tresiba
Costco $54.49 per box of 5 pens $84.49 per box of 5 pens
Walmart $74.97 per box of 5 pens $109.97 per box of 5 pens
Rexall $84.99 per box of 5 pens $122.99 per box of 5 pens
Shoppers Drug Mart $92.99 per box of 5 pens $132.99 per box of 5 pens

Frequently Asked Questions

Which is cheaper, Lantus or Tresiba?
Lantus is generally cheaper, starting at $55.00 per box of 5 pens compared to $85.00 per box of 5 pens for Tresiba. The lowest price is at Costco ($54.49 per box of 5 pens).
What is the difference between Lantus and Tresiba?
Lantus (insulin glargine) and Tresiba (insulin degludec) are different medications in the diabetes category.
Is Lantus or Tresiba covered by provincial drug plans?
Lantus: General Benefit on the Ontario Drug Benefit formulary. Tresiba: General Benefit on the Ontario Drug Benefit formulary.

Last updated: 2026-02-26

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