Skip to main content
Compare

Hydrochlorothiazide starts at $8.00 per month, while Chlorthalidone starts at $10.00 per month in Canada. Hydrochlorothiazide contains HCTZ 25mg, while Chlorthalidone contains chlorthalidone. Last updated: 2026-02-26.

Head-to-Head Comparison

Hydrochlorothiazide Chlorthalidone
Price Range $8–$25 per month $10–$28 per month
Cheapest Pharmacy Costco ($7.99 per month) Costco ($9.49 per month)
Generic Name HCTZ 25mg chlorthalidone
Route Oral tablet Oral tablet
Category Cardiovascular Cardiovascular
ODB Coverage General Benefit General Benefit

Pharmacy Total Breakdown

Pharmacy Hydrochlorothiazide Chlorthalidone
Costco $7.99 per month $9.49 per month
Walmart $17.47 per month $19.97 per month
Rexall $22.79 per month $25.49 per month
Shoppers Drug Mart $24.49 per month $27.49 per month

Frequently Asked Questions

Which is cheaper, Hydrochlorothiazide or Chlorthalidone?
Hydrochlorothiazide is generally cheaper, starting at $8.00 per month compared to $10.00 per month for Chlorthalidone. The lowest price is at Costco ($7.99 per month).
What is the difference between Hydrochlorothiazide and Chlorthalidone?
Hydrochlorothiazide (HCTZ 25mg) and Chlorthalidone (chlorthalidone) are different medications in the cardiovascular category.
Is Hydrochlorothiazide or Chlorthalidone covered by provincial drug plans?
Hydrochlorothiazide: General Benefit on the Ontario Drug Benefit formulary. Chlorthalidone: General Benefit on the Ontario Drug Benefit formulary.

Last updated: 2026-02-26

Get a prescription