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Sertraline starts at $10.00 per month, while Escitalopram starts at $11.00 per month in Canada. Escitalopram contains escitalopram (Cipralex, Lexapro), while Sertraline contains sertraline (Zoloft). Last updated: 2026-02-26.

Head-to-Head Comparison

Escitalopram Sertraline
Price Range $11–$29 per month $10–$28 per month
Cheapest Pharmacy Costco ($10.99 per month) Costco ($9.49 per month)
Generic Name escitalopram (Cipralex, Lexapro) sertraline (Zoloft)
Route Oral tablet Oral tablet
Category Mental Health Mental Health
ODB Coverage General Benefit General Benefit

Pharmacy Total Breakdown

Pharmacy Escitalopram Sertraline
Costco $10.99 per month $9.49 per month
Walmart $21.47 per month $19.97 per month
Rexall $26.99 per month $25.49 per month
Shoppers Drug Mart $28.99 per month $27.49 per month

Frequently Asked Questions

Which is cheaper, Escitalopram or Sertraline?
Sertraline is generally cheaper, starting at $10.00 per month compared to $11.00 per month for Escitalopram. The lowest price is at Costco ($9.49 per month).
What is the difference between Escitalopram and Sertraline?
Escitalopram (escitalopram (Cipralex, Lexapro)) and Sertraline (sertraline (Zoloft)) are different medications in the mental health category.
Is Escitalopram or Sertraline covered by provincial drug plans?
Escitalopram: General Benefit on the Ontario Drug Benefit formulary. Sertraline: General Benefit on the Ontario Drug Benefit formulary.

Last updated: 2026-02-26