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Sertraline starts at $8/mo, while Escitalopram starts at $10/mo in Canada. Escitalopram contains escitalopram (Cipralex, Lexapro), while Sertraline contains sertraline (Zoloft). Last updated: 2026-02-26.

Head-to-Head Comparison

Escitalopram Sertraline
Price Range $10–$22/mo $8–$20/mo
Cheapest Pharmacy Costco ($6.50/mo) Costco ($5.00/mo)
Generic Name escitalopram (Cipralex, Lexapro) sertraline (Zoloft)
Route Oral tablet Oral tablet
Category Mental Health Mental Health
ODB Coverage General Benefit General Benefit

Pharmacy Price Breakdown

Pharmacy Escitalopram Sertraline
Costco $6.50/mo $5.00/mo
Walmart $11.50/mo $10.00/mo
Rexall $14.00/mo $12.50/mo
Shoppers Drug Mart $16.00/mo $14.50/mo

Frequently Asked Questions

Which is cheaper, Escitalopram or Sertraline?
Sertraline is generally cheaper, starting at $8.00/mo compared to $10.00/mo for Escitalopram. The lowest price is at Costco ($5.00/mo).
What is the difference between Escitalopram and Sertraline?
Escitalopram (escitalopram (Cipralex, Lexapro)) and Sertraline (sertraline (Zoloft)) are different medications in the mental health category.
Is Escitalopram or Sertraline covered by provincial drug plans?
Escitalopram: General Benefit on the Ontario Drug Benefit formulary. Sertraline: General Benefit on the Ontario Drug Benefit formulary.

Last updated: 2026-02-26

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