Skip to main content
Compare

Duloxetine starts at $12/mo, while Effexor starts at $12/mo in Canada. Duloxetine contains duloxetine (Cymbalta), while Effexor contains venlafaxine XR. Last updated: 2026-02-26.

Head-to-Head Comparison

Duloxetine Effexor
Price Range $12–$25/mo $12–$25/mo
Cheapest Pharmacy Costco ($8.00/mo) Costco ($8.00/mo)
Generic Name duloxetine (Cymbalta) venlafaxine XR
Route Oral tablet Oral capsule
Category Mental Health Mental Health
ODB Coverage General Benefit General Benefit

Pharmacy Price Breakdown

Pharmacy Duloxetine Effexor
Costco $8.00/mo $8.00/mo
Walmart $14.00/mo $14.00/mo
Rexall $17.00/mo $17.00/mo
Shoppers Drug Mart $19.50/mo $19.50/mo

Frequently Asked Questions

Which is cheaper, Duloxetine or Effexor?
Duloxetine is generally cheaper, starting at $12.00/mo compared to $12.00/mo for Effexor. The lowest price is at Costco ($8.00/mo).
What is the difference between Duloxetine and Effexor?
Duloxetine (duloxetine (Cymbalta)) and Effexor (venlafaxine XR) are different medications in the mental health category. Duloxetine is a oral tablet, while Effexor is a oral capsule.
Is Duloxetine or Effexor covered by provincial drug plans?
Duloxetine: General Benefit on the Ontario Drug Benefit formulary. Effexor: General Benefit on the Ontario Drug Benefit formulary.

Last updated: 2026-02-26

Get a prescription