Mental Health Comparison
Bupropion vs Sertraline
Price comparison in Canada
Sertraline starts at $10.00 per month, while Bupropion starts at $16.00 per month in Canada. Bupropion contains bupropion (Wellbutrin), while Sertraline contains sertraline (Zoloft). Last updated: 2026-02-26.
Head-to-Head Comparison
| Bupropion | Sertraline | |
|---|---|---|
| Price Range | $16–$38 per month | $10–$28 per month |
| Cheapest Pharmacy | Costco ($15.49 per month) | Costco ($9.49 per month) |
| Generic Name | bupropion (Wellbutrin) | sertraline (Zoloft) |
| Route | Oral tablet | Oral tablet |
| Category | Mental Health | Mental Health |
| ODB Coverage | General Benefit | General Benefit |
Pharmacy Total Breakdown
| Pharmacy | Bupropion | Sertraline |
|---|---|---|
| Costco | $15.49 per month | $9.49 per month |
| Walmart | $27.97 per month | $19.97 per month |
| Rexall | $34.99 per month | $25.49 per month |
| Shoppers Drug Mart | $37.99 per month | $27.49 per month |
Full Drug Pages
Frequently Asked Questions
- Which is cheaper, Bupropion or Sertraline?
- Sertraline is generally cheaper, starting at $10.00 per month compared to $16.00 per month for Bupropion. The lowest price is at Costco ($9.49 per month).
- What is the difference between Bupropion and Sertraline?
- Bupropion (bupropion (Wellbutrin)) and Sertraline (sertraline (Zoloft)) are different medications in the mental health category.
- Is Bupropion or Sertraline covered by provincial drug plans?
- Bupropion: General Benefit on the Ontario Drug Benefit formulary. Sertraline: General Benefit on the Ontario Drug Benefit formulary.
Last updated: 2026-02-26