Mental Health Comparison
Bupropion vs Sertraline
Price comparison in Canada
Sertraline starts at $8/mo, while Bupropion starts at $15/mo in Canada. Bupropion contains bupropion (Wellbutrin), while Sertraline contains sertraline (Zoloft). Last updated: 2026-02-26.
Head-to-Head Comparison
| Bupropion | Sertraline | |
|---|---|---|
| Price Range | $15–$30/mo | $8–$20/mo |
| Cheapest Pharmacy | Costco ($11.00/mo) | Costco ($5.00/mo) |
| Generic Name | bupropion (Wellbutrin) | sertraline (Zoloft) |
| Route | Oral tablet | Oral tablet |
| Category | Mental Health | Mental Health |
| ODB Coverage | General Benefit | General Benefit |
Pharmacy Price Breakdown
| Pharmacy | Bupropion | Sertraline |
|---|---|---|
| Costco | $11.00/mo | $5.00/mo |
| Walmart | $18.00/mo | $10.00/mo |
| Rexall | $22.00/mo | $12.50/mo |
| Shoppers Drug Mart | $25.00/mo | $14.50/mo |
Full Drug Pages
Frequently Asked Questions
- Which is cheaper, Bupropion or Sertraline?
- Sertraline is generally cheaper, starting at $8.00/mo compared to $15.00/mo for Bupropion. The lowest price is at Costco ($5.00/mo).
- What is the difference between Bupropion and Sertraline?
- Bupropion (bupropion (Wellbutrin)) and Sertraline (sertraline (Zoloft)) are different medications in the mental health category.
- Is Bupropion or Sertraline covered by provincial drug plans?
- Bupropion: General Benefit on the Ontario Drug Benefit formulary. Sertraline: General Benefit on the Ontario Drug Benefit formulary.
Last updated: 2026-02-26